To configure the FTP server with Secure Sockets Layer (SSL), you can follow instructions in https://docs.microsoft.com/en-us/iis/publish/using-the-ftp-service/using-ftp-over-ssl-in-iis-7.
The following highlights the important settings for configuring SSL on an FTP site:
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The Physical path must be the full path to the Web server Web root.
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The FTP site must be set to Require SSL or Allow SSL.
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An SSL certificate must be selected.
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The Read and Write permissions must be enabled.
When you configure the Web Server profile in PowerBuilder that connects with an SSL Web server, you should input the HTTPS listener and port number for the Web server.