PowerBuilder IDE 2022 and PowerBuilder Runtime 2022 must exactly match with each other by major version numbers. Unlike IDE 2021 which can support Runtime 2021 and 2019 R3, IDE 2022 can only support Runtime 2022; it cannot support Runtime 2021 or earlier. For more, see Selecting a version of PowerBuilder Runtime for the PowerBuilder IDE in Application Techniques.
The application executable compiled with PowerBuilder Runtime 2022 can only work with PowerBuilder Runtime 2022. For more, see Selecting a version of PowerBuilder Runtime for the application executable in Application Techniques.