You may encounter a 404 - File or directory not found error, when you start to run an application.
Cause: The Appeon folder is not in the application-related IIS home directory (For example: your Appeon Server Web Component might be installed in c:\Program Files (x86)\Appeon\WebComponent2016 by default, if you did not change the path when installing it).
Solution: Copy the Appeon folder to the application-related IIS home directory (for example: C:\inetpub\wwwroot) to solve this issue.