Although PowerServer Toolkit 2020 MR can work with PowerBuilder 2019 R2 and 2019 R3, PowerServer Toolkit 2020 MR installs different files for PowerBuilder 2019 R2 and 2019 R3; therefore if PowerBuilder 2019 R2/R3 is re-installed then PowerServer Toolkit 2020 MR must be re-installed as well, and PowerServer Toolkit 2020 MR must be installed after PowerBuilder 2019 R2/R3 is installed.
If you want to upgrade PowerBuilder 2019 R2 and PowerServer Toolkit 2020 GA to PowerBuilder 2019 R3 and PowerServer Toolkit 2020 MR, you can directly run the installer to upgrade them.