You can upgrade an InfoMaker application from any version of InfoMaker directly to InfoMaker 2019 R2.
Before you upgrade, read the "Upgrading PowerBuilder Applications" technical document at https://docs.appeon.com/pb2019r2/upgrading_pb_apps/index.html to learn about changes in InfoMaker that might affect your application. Topics with IM in parentheses after their titles apply to InfoMaker.